A successful "house tuner" in New York City, who calibrates the sound in people's homes in order to adjust their moods, meets a client with a problem he can't solve.
Jo, the mother of seven children, divorces her second husband in order to marry Jake, a successful but promiscuous screenwriter. Though they are physically and emotionally compatible, they are slowly torn apart.
On the outside, Helen has it all – a loving family and a successful career – but when her suppressed mental illness resurfaces, the world crumbles around her. Crippled by depression, Helen finds solace through her friendship with Mathilda, a kindred spirit struggling with bipolar disorder.