Loosely inspired by the video game of the same name, ninja Ryu must take on an evil corporation dabbling in illegal genetic experiments to create demonic mutants.
Two years after the events of the Fourth Great Ninja War, the moon that Hagoromo Otsutsuki created long ago to seal away the Gedo Statue begins to descend towards the world, threatening to become a meteor that would destroy everything on impact. Amidst this crisis, a direct descendant of Kaguya Otsutsuki named Toneri Otsutsuki attempts to kidnap Hinata Hyuga but ends up abducting her younger sister Hanabi. Naruto and his allies now mount a rescue mission before finding themselves embroiled in a final battle to decide the fate of everything.
A mysterious group of ninjas makes a surprise attack on the Konohagakure, which takes great damage. The nightmare of another Shinobi World War could become a reality. Sasuke, who was still a missing nin from Konoha trying to kill his brother, Itachi, appears for the second time in front of Naruto at an unknown location to prevent it from happening.
Increasingly disturbed by the dark energies building within him, Ryu is confronted by Shun, a boy claiming to be the brother he never knew. But before Ryu can consider whether Shun's timely appearance might be more than coincidental, Shun is kidnapped by Shadowlaw. To recover Shun, Ryu must undertake the ultimate journey of self-discovery and learn to control the power threatening to consume him.