Two women with a passion for motorcycles meet while going through rehab. When they discover they've both longed to ride Captain America's red, white, and blue chopper from Easy Rider, they escape the rehab clinic and hit the highway in search of their dream bike.
Taking a break from their dreary lives, close friends Thelma and Louise embark on a short weekend trip that ends in unforeseen incriminating circumstances. As fugitives, both women rediscover the strength of their bond and their newfound resilience.
While Native American Wolf is being pursued by the FBI for having taken the law into his own hands, when his mother was raped and killed on their reservation he crosses paths with Cash, a down and out musician who is coping with the end of his marriage. An unlikely friendship develops, as they ride together towards the Teton mountain range, where Wolf will spread his mothers ashes.
After a chance encounter, headstrong Kathy is drawn to Benny, member of Midwestern motorcycle club the Vandals. As the club transforms into a dangerous underworld of violence, Benny must choose between Kathy and his loyalty to the club.
Wyatt and Billy, two Harley-riding hippies, complete a drug deal in Southern California and decide to travel cross-country in search of spiritual truth.