Simon Henderson is at boarding school in Canada while his father works in Hong Kong, and his mother lives in England. When his parents visit him in the holidays, Simon discovers that his mother has schizophrenia.
A man living in the towering shadow of his aging father finds it difficult to start a new chapter in his life by marrying his girlfriend and moving to California.
Dr. Matthew Clark is the head of a state institution for intellectually disabled children. Jean Hansen, a former music teacher anxious to give her life some meaning, joins the staff of the hospital. Jean, who tries to shelter the children with her love, suspiciously regards Dr. Clark's stern training methods. She becomes emotionally involved with 12-year-old Reuben Widdicombe, who has been abandoned by his divorced parents.
Milly and Louis, and their recently-widowed mom, Charlene, move to a new neighborhood. Once there, they all deal with a variety of personal problems, but Milly finds a friend in Eric, her autistic next door neighbor. Eric has a fascination with flight, and as the story progresses, he exerts an enthralling force of change on all those around him.
Corinne is a single mother of twin 5-year-old boys, Steven and Phillip, who are diagnosed with autism. Public school officials threaten to remove them from school due to their behavior, but through therapy, the boys are able to make major strides in their capabilities. A decade later, teens Steven and Phillip seek to prove they can handle high school while still struggling with their disorder.