Flea is spending his vacation at a music camp in a spooky old mansion. But he is more interested in scaring people with practical jokes, than in music.
A young neurosurgeon inherits the castle of his grandfather, the famous Dr. Victor von Frankenstein. In the castle he finds a funny hunchback, a pretty lab assistant and the elderly housekeeper. Young Frankenstein believes that the work of his grandfather was delusional, but when he discovers the book where the mad doctor described his reanimation experiment, he suddenly changes his mind.
Singer-songwriter Winslow Leach seeks revenge on the nefarious music producer Swan, who steals both Winslow's music and his favorite singer for the grand opening of Swan's new rock palace, the Paradise.
Seymour Krelborn is a nerdy orphan working at Mushnik's, a flower shop in urban Skid Row. He harbors a crush on fellow co-worker, Audrey Fulquard, and is berated by Mr. Mushnik daily. One day, Seymour finds a very mysterious unidentified plant which he calls Audrey II. The plant seems to have a craving for blood and soon begins to sing for its supper.
An obscure Eastern cult that practices human sacrifice pursues Ringo after he unknowingly puts on a ceremonial ring (that, of course, won't come off). On top of that, a pair of mad scientists, members of Scotland Yard, and a beautiful but dead-eyed assassin all have their own plans for the Fab Four.