When his home of New Eden is destroyed by a revitalized Brotherhood and its new Vamp leader, Martin finds himself alone in the badlands of America with only the distant memory of his mentor and legendary vampire hunter, Mister, to guide him.
Whilst vacationing in the Carpathian Mountain, two couples stumble across the remains of Count Dracula's castle. The Count's trusted servant kills one of the men, suspending the body over the Count's ashes so that the blood drips from the corpse and saturates the blackened remains. The ritual is completed, the Count revived and his attentions focus on the dead man's wife who is to become his partner; devoted to an existence of depravity and evil.
When Hellboy, Liz Sherman, and Abe Sapien are assigned to investigate the ghost-infested mansion of a publicity-hound billionaire, they uncover a plot to resurrect a beautiful yet monstrous vampire from Professor Bruttenholm’s past. But before they can stop her bloodbath, Hellboy will have to battle harpies, hellhounds, a giant werewolf, and even the ferocious goddess Hecate herself.
In the heart of Styria the Karnstein Family, even after their mortal deaths, rise from their tombs spreading evil in the countryside in their lust for fresh blood. Baron Hartog whose family are all victims of Karnstein vampirism, opens their graves and drives a stake through their diabolical hearts. One grave he cannot locate is that of the legendary beautiful Mircalla Karnstein. Years of peace follow that grisly night until Mircalla reappears to avenge her family's decimation and satisfy her desire for blood.
In an alternate world, humanity and vampires have warred for centuries. After the last Vampire War, the veteran Warrior Priest lives in obscurity with other humans inside one of the Church's walled cities. When the Priest's niece is kidnapped by vampires, the Priest breaks his vows to hunt them down. He is accompanied by the niece's boyfriend, who is a wasteland sheriff, and a former Warrior Priestess.