The film starts in medieval times, when a young couple is attacked by the Knights Templar. The man is instantly killed, and the woman is carried away to the Templars' castle, where she is sacrificed.
Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.
The chilling and relentless Jigsaw killer returns to terrorize the city once again. When a gruesome murder victim emerges with unmistakable traces of Jigsaw's sinister methods, Detective Eric Matthews is thrust into a high-stakes investigation. To his surprise, apprehending Jigsaw seems almost too easy, but what he doesn't realize is that being caught is merely another piece of Jigsaw's intricate puzzle.
Jigsaw has disappeared. Along with his new apprentice Amanda, the puppet-master behind the cruel, intricate games that have terrified a community and baffled police has once again eluded capture and vanished. While city detectives scramble to locate him, Doctor Lynn Denlon and Jeff Reinhart are unaware that they are about to become the latest pawns on his vicious chessboard.