Trapped in their New York brownstone's panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg Altman and her young daughter Sarah play a deadly game of cat-and-mouse with three intruders - Burnham, Raoul and Junior - during a brutal home invasion. But the room itself is the focal point because what the intruders really want is inside it.
After Margaret, a divorcée living in Dublin, loses her teenage son, she develops an unorthodox relationship with Joe, a homeless youth. Their tentative trust is threatened by his involvement with a violent gang and the escalation of her ex-husband's grieving rage.
A young man receives an emergency phone call on his cell phone from an older woman. She claims to have been kidnapped – and the kidnappers have targeted her husband and child next.
A teenage girl living with schizophrenia begins to suspect her neighbor has kidnapped a child. Her parents try desperately to help her live a normal life, without exposing their own tragic secrets, and the only person who believes her is Caleb – a boy she isn’t even sure exists.