A gunfighting stranger comes to the small settlement of Lago. After gunning down three gunmen who tried to kill him, the townsfolk decide to hire the Stranger to hold off three outlaws who are on their way.
During a shootout in a saloon, Sheriff Hunt injures a suspicious stranger. The doctor's assistant, wife of the local foreman, tends to him in prison. That night, the town is attacked and they both disappear—only the arrow of a cannibal tribe is found. Hunt and a few of his men go in search of the prisoner and the foreman's wife.
A Southern Colonel, his three sons, and a card shark embark on an odyssey through the Southwest carrying a coffin full of stolen money with which the Colonel plans to revive the Confederacy.