The MacGregors, horse ranchers of Scottish descent, are underway to the market when they are robbed of their horses by a gang under the helm of a corrupt sheriff. One of the brothers infiltrates the gang but his first attempt tries to play them backfires.
Several pillars of society have robbed an Army safe containing $100,000 so they can buy the land upon which the coming railroad will be built. But they haven't reckoned on the presence of the master gunslinger, Sabata.
Wily roving gunslinger Sartana arrives in a small town and tries to find a hidden fortune of half a million dollars in gold and two million dollars in counterfeit money. Naturally, a bunch of other treacherous folks who include conniving widow Senora Manassas, shrewd fellow gunslinger Grand Full, and the vicious and unhinged General Monk are also looking to get their greedy hands on said fortune.
Posing as a hangman, Mace Bishop arrives in town with the intention of freeing a gang of outlaws, including his brother, from the gallows. Mace urges his younger brother to give up crime. The sheriff chases the brothers to Mexico. They join forces, however, against a group of Mexican bandits.