Detroit business tycoon, Steve Bradford, tells his board of directors without explanation that he is taking a leave of absence. He travels to his small hometown, where it turns out that his goal is to find a son he put up for adoption 20 years before.
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After her adoptive mother dies, Hortense, a successful black optometrist, seeks out her birth mother. She's shocked when her research leads her to Cynthia, a working class white woman.
John, a 35-year-old window cleaner, has dedicated his life to bringing up his 4-year-old son, Michael, after the child's mother left them soon after giving birth. When John is given only a few months left to live, he attempts to find a new, perfect family for Michael, determined to shield him from the terrible reality of the situation.
Desmond Doyle is devastated when his wife abandons their family on the day after Christmas. His unemployment, and the fact that there is no woman in the house to care for the children—Evelyn, Dermot and Maurice—make it clear to the authorities this is an untenable situation. The Catholic Church and the Irish courts decide to put the Doyle children into Church-run orphanages.
In 1960s Los Angeles an energetic widow and her six children try to make a dream of theirs come true: to have a home of their own. They leave L.A. and head for the countryside, all the while facing numerous difficulties and obstacles during their journey.
In the late 1970s, when a mentally handicapped teenager is abandoned, a gay couple takes him in and becomes the family he's never had. But once the unconventional living arrangement is discovered by authorities, the men must fight the legal system to adopt the child.