Mexican bandit Jose Esqueda resents settlers in the Brownsville, Texas region, and conducts raids against them. He threatens to burn down homes, including the ranch house King Cameron has just built for his wife Cordelia.
A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.
Whenever it becomes known how good he is with guns, ex-gunman George and his wife Dora have to flee the town, in fear of all the gunmen who might want to challenge him. Unfortunately he again spills his secret when he's drunk. All citizens swear to keep his secret and support him to give up his guns forever -- but a boy tells the story to a gang of wanted criminals. Their leader threatens to burn down the whole town, if he doesn't duel him.
Running from the law after a bank robbery in Mexico, Dad Longworth finds an opportunity to take the stolen gold and leave his partner Rio to be captured. Years later, Rio escapes from the prison where he has been since, and hunts down Dad for revenge. Dad is now a respectable sheriff in California, and has been living in fear of Rio's return.
Three of the original five "young guns" — Billy the Kid, Jose Chavez y Chavez, and Doc Scurlock — return in Young Guns, Part 2, which is the story of Billy the Kid and his race to safety in Old Mexico while being trailed by a group of government agents led by Pat Garrett.