Ramiro and Teófilo are great friends and endure their misfortunes together. Their attempts to succeed as artists fail, so they both promise that the first to die will become the guide to the survivor's life.
Laura has been with Antonio all her life and, just when she begins to wonder if that is really the life she wants, Sergio and Siena cross paths in their lives. Sergio is a former high school classmate and Siena, his millennial girlfriend who arrives to revolutionize everyone's lives. Laura, Raquel and Cris, close friends for years, convince their respective husbands to play a game that Siena proposes to them: the game of keys. The game consists of everyone putting their keys in a bowl. At random, each one chooses some keys and he must go to spend the night with the owner of the keys. This game will revolutionize the group of friends and their lives. It will make them discover who they are and what they really want.
Mexico City, or "Chilangolandia," is a chaotic metropolis where millions of stories take place every day. Some of them are part of this fun comedy full of familiar characters and others that defy stereotypes. Ramiro is a taxi driver who hopes his problems will end when his nephew "El Chulo" becomes a national soccer star. On the other hand, Carmen and Miguel are couple who unexpectedly receive a suitcase with a large sum of money, just what they need to get out of their financial situation. But when the true owners of the cash realize that it fell into the wrong hands, endless adventures and misunderstandings break out within this complex city.
Mary and her friend, Rachel, are new students at St. Francis Academy, a boarding school run by the iron fist of Mother Superior. The immature teens grow bored and begin playing pranks on both the unsuspecting nuns and their unpleasant classmates, becoming a constant thorn in Mother Superior's side. However, as the years pass, Mary and Rachel slowly mature and begin to see the nuns in a different light.