Dr. Watson is serving as resident doctor at Musgrave Manor in Northumberland, a stately home which is also used as a hospital for a number of servicemen suffering from Posttraumatic stress disorder.
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The Good Comrades are a collection of varied gentlemen who crave one thing - solitude. They reside at Drearcliff House, ancestral home of their eldest member. All seems serene and convivial until one by one the members begin to perish in the most grisly of manners. Foul play is suspected by the Good Comrades' insurance agent, who turns to Sherlock Holmes and Dr. John Watson for guidance.
In World War II, a British secret agent carrying a vitally important document is kidnapped en route to Washington. The British government calls on Sherlock Holmes to recover it.
When a woman is found dead with her throat torn out, the local villagers blame a supernatural monster. But Sherlock Holmes, who gets drawn into the case from nearby Quebec, suspects a human murderer.
Mary Morstan has received a pearl in the post every year since her father's disappearance. This leads Holmes and Watson to the truth about a secret pact between four convicts during the Indian Rebellion of 1857.
Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.
Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.