A young girl is being tried for murder. Her defense attorney attempts to show how her descent into a life of crime, prostitution and degradation was caused by her puritanical, religious fanatic mother.
The gruesome death of a prostitute brings suspicion on one of her clients, James Wayland, a brilliant, self-destructive and epileptic heir to a textile fortune. So detectives Braxton and Kennesaw take Wayland in for questioning, thinking they can break the man. But despite his troubles, Wayland is a master of manipulation, and during the interrogation, he begins to turn the tables on the investigators, forcing them to reveal their own sinister sides.
Holly Parker, the wife of a wealthy diplomat, is compromised by the accidental death of a man who has been romantically pursuing her. She is forced by her mother-in-law to assume a new identity in order to save the reputation of her husband and infant son. She wanders the world, trying to forget her heartbreak with the aid of alcohol and unsavory men. Eventually returning to the city of her downfall, she murders a blackmailer who threatens to expose her past. Amazingly, Holly is represented at her murder trial by her now adult son, who has become a public defender. In the hope of protecting her family, she refuses to reveal her real name and is known to the court as "Madame X".
In 1989, prostitute Aileen Wuornos befriends and enters a relationship with a young woman named Selby. Determined to straighten out her life, Aileen's limited education lands her back on the corner. She's raped by a trick, who she kills. A string of murder and robbery follows that ultimately leads Aileen to becoming America's first female serial killer.