A town in the Castilian highlands is subjugated by the tyranny of a brutal cacique, who imposes his abuses. The bandit Salvador, crouched in the mountains, is his main concern.
Ana and her two best friends, Maria and Paula, navigate life in their oppressive countryside village. Whilst their families struggle in the poppy fields harvesting opium, the girls try to grow alongside the creeping terror of their cartel oppressors.
In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.
Young teen girl Xiu Xiu is sent away to a remote corner of the Sichuan steppes for manual labor in 1975 (sending young people to there was a part of Cultural Revolution in China). A year later, she agrees to go to even more remote spot with a Tibetan saddle tramp Lao Jin to learn horse herding.
After inheriting a remote Montana house, Jackson moves there from New York with his partner Grace, and the couple soon welcome a child. As Jackson becomes increasingly absent and rural isolation sets in, Grace struggles with loneliness, creative frustration, and unresolved emotional wounds. What begins as an attempt at renewal gradually turns into an intense psychological descent, placing strain on their relationship and exposing the fragile balance between love, identity, and motherhood.
The story of a young boy in the Midwest is told simultaneously with a tale about a young girl in New York from fifty years ago as they both seek the same mysterious connection.