Cha Yo-Han—an arrogant but genius doctor of anesthesiology—and Kang Shi-Young—a smart, warm resident of anesthesiology—work together to help people with mysterious cases of acute or chronic pain.
Ji-Sook goes through a difficult period, due to her father's private loan. She begins living as Eun-Ha. Eun-Ha is from a wealthy family and looks like Ji-Sook. When Min-Woo was only seven years old, he became the successor of a large corporation which his family ran. Due to his position, he cannot reveal his feelings. Through his family, he meets Eun-Ha. He notices she is different from other wealthy woman that he has met. Min-Woo has feelings for her.
Yoon Soo-wan and Park Dong-joo were each other's first loves, but were forced to separate due to painful family circumstances. Soo-wan, who had been blind, eventually undergoes an eye transplant surgery that restores her sight.
Heo Im (Kim Nam-Gil), Joseon'da akupunktur ve moksibüsyonun en iyisi olarak kabul edilen oryantal bir doktordur. Düşük statüsünden dolayı başarısı engellenir. Bir gün, Heo Im zamanda yolculuk yapar ve günümüz Seul'unde kendisini bulur. Choi Yeon Kyung (Kim Ah-Joong) adında bayan bir doktorla tanışır. Bu doktor sadece modern tıbba inanmaktadır.