When the 1989 "one-hit-wonder" glam-metal band "Sonic Grave" embark on a trip to Coachella in hopes of a comeback, their peyote trip pit stop in Joshua Tree incites an "unworldly" viscous attack, and they must "rock" themselves out of harms way.
The film follows a petty rock band called the Winners, consisting of vocalist Joey Winner, bassist Jennifer, guitarist Tyler, drummer Sam, and French-Canadian roadie Hugo, along with their sleazy manager Jeff, as they tour across Canada and the USA after Jennifer is turned into a vampire by Queeny. Meanwhile, a vampire hunter who is afraid of the dark named Eddie Van Helsing quickly chases them down.
In Venice Beach, naive Midwesterner JB bonds with local slacker KG and they form the rock band Tenacious D. Setting out to become the world's greatest band is no easy feat, so they set out to steal what could be the answer to their prayers... a magical guitar pick housed in a rock-and-roll museum some 300 miles away.
Mega-promoter Colin Beverly plans to sabotage the New Year's 1983 concert of small-time operator Max Wolfe. Wolfe's assistants Neil Allen and Willie Loman find romance while trying to save the drugs, violence, and rock and roll from Beverly's schemes.
Jennifer, a gorgeous, seductive cheerleader takes evil to a whole new level after she's possessed by a sinister demon. Now it's up to her best friend to stop Jennifer's reign of terror before it's too late.