Katy Keene, moda ikonu olan bir kadın ve arkadaşlarının hikayesini konu ediyor. Ünlü bir moda ikonu olan Katy Keene ve kızlardan oluşan grubu kendilerini New York’ta büyük bir maceranın içerisinde bulur. Onlar bir yandan hayallerindeki mesleklere sahip olmak için çabalarken bir yandan da aşk hayatlarını yoluna koymak için mücadele etmek zorunda kalır.
Chiyuki Fujito was going to be a professional runway model until she stopped growing. Poor Ikuto Tsumura is not even sure if he wants to be a fashion designer because of his family responsibilities. Faced with overwhelming adversity, they need to decide if their dreams are worth pursuing. It’s not impossible – they’ll just have to be creative in how they get there!
Shion and Rui are the dream team when it comes to hitting on women. Tonight was going to be another night of hooking up with girls for Shion, but he ended up taking a strange drug. When he woke up... he'd turned into a girl?! Rui came looking for Shion, but didn't recognize him, and started hitting on him...
Izumi was born in a family of celebrities. His father is a singer, his mother an artist, his older brother the lead vocalist for the popular band CRUSHERZ. Izumi himself, however, is just a nerdy college student. He loves the manga "Magical Girl Lala Lulu" and dreams of becoming a manga writer himself. One day he is roped into filming a commercial where he wears a dress. Another actor on the set, Ryōma Ichijō, mistakes him for a woman and falls in love at first sight. As it turns out, though, they met ten years in the past. And Ryōma's feelings don't change when he finds out Izumi is a boy.
Mizuki disguises herself as a boy and transfers to the same all-boys' high school her idol, Izumi Sano, a high-jump athlete who gave up on the sport, attends. In between their classmates' antics she tries to get him to jump again.
Betty Suarez sert, inatçı, hassas ve sevgi dolu biri. Ancak geleneksel anlamda şık ya da çekici değil. Bu yüzden kibirli moda dergisi Mode'da işe başladığında zorlu bir mücadeleyle karşı karşıya kalır.