Honda Goro the son of a famous baseball player loves nothing more than baseball itself. His biggest dream is to show his father that he can become the best pitcher in the world despite all the hardships he had to endure he keeps on running towards his goal at full speed.
Attacker You! is the story of ambitious and energetic 13-year-old junior high schoolgirl You Hazuki (variously known as "Mila," "Jeanne" or "Juana" in Western dubbed versions of the anime), who moves to Tokyo from Osaka to live with her father Toshihiko, a cameraman recently returned from Peru, and attend school. You's mother is not in the picture, having left when You was very young. Also living with You and her father is her younger brother Sunny, who is very attached to his older sister and tends to follow her everywhere she goes, including to school and to her volleyball matches. You is also curious about Kyushi Tajima, the pretty blonde woman whom she sees covering volleyball games on television, and about why her father becomes very angry whenever You mentions her.
Shin-chan, the boy next door, is a walking disaster, creating chaos wherever he goes. With the body of a child and the mind of an adult, Shinchan is wreaking more havoc than any child before. Shin-chan is carefree, optimistic and gets excited about everything. This 5 year-old likes to do things his way.
Eiichirō Maruo (nicknamed "Ei-chan" for his grades being straight "A") is an honor student, bookworm, and is not interested in anything other than studying. In order to solve his problem of lacking physical strength, he enrolled a tennis school and soon found the fascinating side of tennis. Being a tennis newbie lacking physical strength, he supplement his shortcomings with his excellent observing and analyzing skills.
The anime follows a salaryman who has a chance meeting with a girl named Ai on the train. They begin to meet every Monday on the train, with the man serving as her bodyguard on the crowded commute while they chat.
Sora, a young girl from Japan, comes to America in search of her dream. She wants, with all her heart, to be a member of the famous Kaleido Stage, a combination of musicals, acrobatics and magical effects. With the help of her friends, she struggles to make this dream come true.