The story takes place in 19th century Europe, and revolves around John Watson. He is scouted by the government to become a secret agent. However, Watson lives in a world where "Frankensteins"—human corpses that are re-purposed with a false soul in order to use them as laborers—are used to improve industrial development.
It's the year of destiny, and 15 year old Kamui Shiro, a powerful psychic, has returned to Toyko after a 6 year absence, having left when he was very young. He wants to be with his childhood friends, Fuma (his best friend) and Kotori, Fuma's little sister (and Kamui's possible girlfriend). He wants to protect them from all dangers, but destiny and fate are haunting Kamui and pulling in himself and his beloved childhood friends. It is his destiny and his sole decision to decide the fate of the world, no matter if he wants the role or not. Now it is a matter of if he will join the side of the Seven Seals and become the Dragon of Heaven to save mankind or join the Seven Angels and become the Dragon of Earth to destroy all civilization so the earth can heal itself from man's destruction.
When an artifact known as the "King's Seal" is stolen during transport from Soul Society, Hitsugaya Toushirou is assigned to retrieve it. Toushirou goes missing after a battle with the thieves, leading Seireitei to suspect him of treachery. They order his immediate capture and execution. Unwilling to believe him capable of such a crime, Ichigo, Rangiku, Rukia, and Renji set out to find Toushirou.
Edo hareminin odalarına yeni gelen iki kadın, burada siyasi entrikaları, rekabeti ve yalnızca gezgin bir ilaç satıcısının yenebileceği intikamcı bir ruhu ortaya çıkarır.
Karakura Şehrinde tanımlanamayan ruhlar ortaya çıkar. Ichigo ve Rukia, bu tuhaf ruhlarla uğraşırken Senna adında gizemli bir “shinigami” ile karşılaşırlar. Senna, “blanks” adı verilen bu ruhları çok çabuk yok eder. Bu arada, Soul Society’de, dünyanın yansımaları gökyüzünde belirmiştir. Tōshirō ve Rangiku, bu tuhaf olayı araştırmak üzere dünyaya gönderilirler. Burada, Ichigo ile karşılaşırlar. Urahara’nın dükkânında olayları tartışırken Urahara onlara bu olaylara iki dünya arasında kalmış bir ruhun neden olduğunu söyler.