Petty crook and cop-killer Martin Rome, in bad shape from wounds in the hospital prison ward, still refuses to help slimy lawyer Niles clear his client by confessing to another crime. Police Lt. Candella must check Niles' allegation; a friend of the Rome family, he walks a tightrope between sentiment and cynicism. When Martin fears Candella will implicate his girlfriend Teena, he'll do anything to protect her. How many others will he drag down to disaster with him?
A mystery writer is intrigued by the tale of notorious criminal Dimitrios Makropolous, whose dead body was found washed up on the shore in Istanbul. He decides to follow the career of Dimitrios around Europe, in order to learn more about the man. Along the way he is joined by the mysterious Mr. Peters, who has his own motivation.
Cleve Marshall, an assistant district attorney, falls for Thelma Jordon, a mysterious woman with a troubled past. When Thelma becomes a suspect in her aunt's murder, Cleve tries to clear her name.
Frank Johnson, a sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor, suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett, Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.
Davey Gordon, a New York City boxer at the end of his career, falls for dancer Gloria Price. However, their budding relationship is interrupted by Gloria's violent boss, Vincent Rapallo, who has eyes for Gloria. The two decide to skip town, but before they can, Vincent and his thugs abduct Gloria, and Davey is forced to search for her among the most squalid corners of the city, with his enemy hiding in the shadows.
New York City detective Daniel Ciello agrees to help the United States Department of Justice eliminate corruption in the police department, as long as he will not have to turn in any close friends. In doing so, Ciello uncovers a conspiracy within the force to smuggle drugs to street informants.