The movie begins at the murder trial of Ethel Saxon, a woman who shot her lover in a crime of passion. During the trial, Edward Weldon, the jury foreman, asks the defendant a question, which ultimately leads to a guilty verdict and a death sentence for her.
Holly Parker, the wife of a wealthy diplomat, is compromised by the accidental death of a man who has been romantically pursuing her. She is forced by her mother-in-law to assume a new identity in order to save the reputation of her husband and infant son. She wanders the world, trying to forget her heartbreak with the aid of alcohol and unsavory men. Eventually returning to the city of her downfall, she murders a blackmailer who threatens to expose her past. Amazingly, Holly is represented at her murder trial by her now adult son, who has become a public defender. In the hope of protecting her family, she refuses to reveal her real name and is known to the court as "Madame X".
A corrupt D.A. with governatorial ambitions is annoyed by an investigative reporter's criticism of his criminal activities and decides to frame the reporter for manslaughter in order to silence him.
Alec Graham is sentenced to death for the murder of his girlfriend Jennie, with whom he spent a weekend at the English country home of the parents of his friend Brian Stanford. Alec’s father, David Graham, a not-so-successful writer and alcoholic who has neglected his son in the past, flies in from Canada to visit his son on death row. David then goes on a quest to try and clear his son’s name while battling “the bottle.”