Kellie Madison

J.D. olarak tanınan John Dorian, dizinin ana karakteridir. J.D.nin doktorluk macerasını izlerken "gerçeküstü" bir hastane olan Sacred Heart Hospital'ın koridorlarında mizahı da trajediyi de birlikte izleyeceğiz. Chris Turk, genç doktorlarımızdan bir diğeridir. J.D.nin kolejdeki en yakın arkadaşı ve seçkin cerrahi grubunun bir üyesidir. Güzel Elliot Reid'in ise tek kusuru gerçek bir asosyal olmasıdır. Gözleri her zaman bu genç doktorların üzerinde olan Dr. Bob, zaman zaman insanı zorlasa da onlar için endişelenen ve onlara yardımcı olmaya çalışan Dr. Perry Cox ve garip hemşire Carla Espinosa, Scrubs'ın diğer karakterleri arasında. J.D.nin baş düşmanı, hastanenin temizlikçisini de unutmamak lazım.

Freddie Moreno had finally escaped from the raucous house of women with whom he grew up. Having achieved some success as head chef at a trendy Chicago restaurant, he's ready for love and everything else that single life has to offer, including hanging out with his best friend and neighbor, Chris. Unfortunately, there's one slight hitch: After the death of his older brother and the collapse of his sister's marriage, goodhearted Freddie took in his impulsive sister-in-law, his pragmatic sister with her 13-year-old daughter and their irascible grandma, who refuses to speak English and only responds in Spanish – even though she understands every word. But while the members of this unconventional brood may test Freddie's patience endlessly, they also support and take care of one another, just as they always have. Now all Freddie has to do is figure out how to maintain his thriving bachelor lifestyle in a house overflowing with estrogen.

Dave McGuiness is about to propose to his longtime girlfriend, but before he does he'll embark on an epic journey across South Chicago to discover whether or not he's ready for a life of marriage.